Angelina, born as a member of the Albanian Arianiti family, was the sixth daughter of Gjergj Arianiti (1383–1462), and Maria Muzaka (1410s–1440s), eldest daughter of Despot Andrea III Muzaka and his wife Anna Zenevisi, Lady of Grabossa.[2][3][4][5] In 1460, she married exiled Serbian ruler Stefan Branković (r. 1458–59), son of the former Despot Đurađ Branković (r. 1427–1456). They met when Stefan came to Northern Albania, to visit Skanderbeg, who was married to Angelina's elder sister Andronika Arianiti. They lived in Shkodër, at the time under Albania Veneta. In 1461, she gave birth to her eldest son Đorđe (anglicised: George), who was named after Skanderbeg and her father Gjergj Arianiti.
Eventually, the couple left Albania for Northern Italy, and acquired castle Belgrado in the region of Friuli. Stefan died in 1476, at family estate in Belgrado. At first, Angelina and their children remained in northern Italy. In 1479, emperor Friedrich III granted them castle Weitensfeld, and Angelina with her children moved to Carinthia.
In 1485, their cousin, titular Serbian Despot Vuk Branković died, and Hungarian king Matthias Corvinus invited Angelina's sons to take over their dynastic inheritance. Angelina and her family went to the Kingdom of Hungary, where her elder son, George, became new titular despot of the Serbian Despotate (1486). The territory of the Despotate had been under the Ottoman Empire since its collapse in 1459. Later Angelina retired in the Krušedol Monastery, in the Fruška Gora mountain of Syrmia, where she died in the beginning of the 16th century.
